BiohacksAI/Mechanism Hypothesis/Vitamin

Vitamin — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19ARCYP2C9NR1I2ESR1CYTOCHROMETDP1CYP1A2THRBCYP3A4NFE2L2CHAINGLI3NUCLEARNR3C1KCNH2RARAESR2CYP19A1PPARGMAPTALDEHYDERXRAHSPB1HTTAPPGPX4PHOSPHOLIPIDSNCATXNRD1TTRGRK2CXCL8SIRT5UCHL5NR2C2RBP4RETINOL-BINDING

38 known targets mapped from PubChem bioassay data

Pathway Context

Nuclear Receptor transcription pathway9 targets overlapping

SUMOylation7 targets overlapping

SUMO E3 ligases SUMOylate target proteins7 targets overlapping

Uncovered Pathway Targets

119 total

ESRRAESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1NR1D2+109 more…

Genes present in the top pathway union that Vitamin does not directly modulate.

Top Stack Candidates

Progesterone

#1 gap-filler · 17 targets covered · evidence score 50.6

score 4,225.143

ESRRAESRRGHNF4AHNF4GNR1H2NR1H4NR2F1NR3C2NR4A2NR5A1NR5A2PGR+5

Luteolin 5,7,3',4'-tetrahydroxy-flavone,

#2 gap-filler · 14 targets covered · evidence score 40.6

score 3,034.53

NR1H2NR1H3AURKBBLMNFKB2PARP1RELATOP1WRNCBR3CYP1A1CYP1B1+2

709 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.